| Robert Downey Jr. | ... | Tony Stark / Iron Man |
| Guy Pearce | ... | Aldrich Killian |
| Paul Bettany | ... | Jarvis (voice) |
| Gwyneth Paltrow | ... | Pepper Potts |
| Rebecca Hall | ... | Maya Hansen |
| Don Cheadle | ... | James Rhodes / War Machine |
| Ben Kingsley | ... | The Mandarin |
| Jon Favreau | ... | Happy Hogan |
| James Badge Dale | ... | Eric Savin |
| William Sadler | ... | Sal Kennedy |
| Stan Lee | ... | Stan the Man (rumored) |
| Yvonne Zima | ... | Miss Elkridge |
| Stephanie Szostak | | |
| Dale Dickey | ... | Mrs. Davis |
| Ty Simpkins | ... | Harley |
| Ashley Hamilton | ... | Jack Taggert |
| Spencer Garrett | ... | Rose Hills Sheriff |
| Bridger Zadina | ... | Richie |
| Indra Patel | ... | Liz Georgoh |
| Chris Gethard | ... | Juan |
| Marco Sanchez | ... | Vice President Rodriguez |
| Xueqi Wang | ... | Dr. Wu |
| Noa Lindberg | ... | Michele Cusick |
| Mark Kubr | ... | Cell Guard #1 |
| Joseph Velez | ... | Villain / Biker |
| Rustam Branaman | ... | Agent Danbury |
| Roy McCrerey | ... | Military Advisor |
| Stephen L. Cohen | ... | Mandarin Guard |
| Jim Gunter | ... | Mr. Davis |
| Mark Robert Thompson | ... | White House Secret Service |
| Lorraine Caporaso | ... | Aristocrat Hotel Guest |
| Carolyn Foland | ... | Waitress |
| Laura Avery | ... | Saloon Girl |
| Crisann Peters | ... | Neptunes Bartender |
| Toochukwu T.C. Anyachonkeya | ... | Party Guest #1 (uncredited) |
| Logan Bennett | ... | Onlooker (uncredited) |
| Sharika Blockett | ... | Onlooker at Hospital (uncredited) |
| Christopher Cozort | ... | Pageant Guest / Saloon Patron(uncredited) |
| Brenden Donovan | ... | Stark Security Guard (uncredited) |
| Steve Earnest | ... | White House Photographer (uncredited) |
| Gregory French | ... | Insurgent (uncredited) |
| Dean Allen Jones | ... | EMT (uncredited) |
| Chad Kurtz | ... | Secret Service Agent (uncredited) |
| Tanner Lagasca | ... | A.I.M. Employee (uncredited) |
| Keri Maletto | ... | Convention Photographer (uncredited) |
| Keith Middlebrook | ... | Agent Adams (uncredited) |
| Brian Patrick Moize | ... | Rose Hill Saloon Patron (uncredited) |
| Eric Perez | ... | Neptune Net Bar Patron (uncredited) |
| Keith Rafalko | ... | Townsman (uncredited) |
| Ray Remillard | ... | VP Senior Staff (uncredited) |
| John L. Smith Jr. | ... | Townsman (uncredited) |
| Gina Travis | ... | Judge 1 (uncredited) |
| Millie Wannamaker | ... | Pagent Guest / TownResident (uncredited) |
| Kenny Waymack Jr. | ... | Party Guest (uncredited) |
| Memi West | ... | Pageant (uncredited) |
| Justin Wheelon | ... | Alex Matthews (uncredited) |
| Lawrence Whitener | ... | Key West Codger (uncredited) |
| Ebony Wilson | ... | Stark Employee (uncredited) |
| Lauren York | ... | Miss Johnson City (uncredited) |