 | Robert Downey Jr. | ... | Tony Stark / Iron Man |
 | Guy Pearce | ... | Aldrich Killian |
 | Paul Bettany | ... | Jarvis (voice) |
 | Gwyneth Paltrow | ... | Pepper Potts |
 | Rebecca Hall | ... | Maya Hansen |
 | Don Cheadle | ... | James Rhodes / War Machine |
 | Ben Kingsley | ... | The Mandarin |
 | Jon Favreau | ... | Happy Hogan |
 | James Badge Dale | ... | Eric Savin |
 | William Sadler | ... | Sal Kennedy |
 | Stan Lee | ... | Stan the Man (rumored) |
 | Yvonne Zima | ... | Miss Elkridge |
 | Stephanie Szostak | | |
 | Dale Dickey | ... | Mrs. Davis |
 | Ty Simpkins | ... | Harley |
 | Ashley Hamilton | ... | Jack Taggert |
 | Spencer Garrett | ... | Rose Hills Sheriff |
 | Bridger Zadina | ... | Richie |
 | Indra Patel | ... | Liz Georgoh |
 | Chris Gethard | ... | Juan |
 | Marco Sanchez | ... | Vice President Rodriguez |
 | Xueqi Wang | ... | Dr. Wu |
 | Noa Lindberg | ... | Michele Cusick |
 | Mark Kubr | ... | Cell Guard #1 |
 | Joseph Velez | ... | Villain / Biker |
 | Rustam Branaman | ... | Agent Danbury |
 | Roy McCrerey | ... | Military Advisor |
 | Stephen L. Cohen | ... | Mandarin Guard |
 | Jim Gunter | ... | Mr. Davis |
 | Mark Robert Thompson | ... | White House Secret Service |
 | Lorraine Caporaso | ... | Aristocrat Hotel Guest |
| Carolyn Foland | ... | Waitress |
| Laura Avery | ... | Saloon Girl |
| Crisann Peters | ... | Neptunes Bartender |
 | Toochukwu T.C. Anyachonkeya | ... | Party Guest #1 (uncredited) |
| Logan Bennett | ... | Onlooker (uncredited) |
| Sharika Blockett | ... | Onlooker at Hospital (uncredited) |
| Christopher Cozort | ... | Pageant Guest / Saloon Patron(uncredited) |
| Brenden Donovan | ... | Stark Security Guard (uncredited) |
 | Steve Earnest | ... | White House Photographer (uncredited) |
 | Gregory French | ... | Insurgent (uncredited) |
 | Dean Allen Jones | ... | EMT (uncredited) |
 | Chad Kurtz | ... | Secret Service Agent (uncredited) |
| Tanner Lagasca | ... | A.I.M. Employee (uncredited) |
 | Keri Maletto | ... | Convention Photographer (uncredited) |
 | Keith Middlebrook | ... | Agent Adams (uncredited) |
 | Brian Patrick Moize | ... | Rose Hill Saloon Patron (uncredited) |
 | Eric Perez | ... | Neptune Net Bar Patron (uncredited) |
 | Keith Rafalko | ... | Townsman (uncredited) |
 | Ray Remillard | ... | VP Senior Staff (uncredited) |
 | John L. Smith Jr. | ... | Townsman (uncredited) |
 | Gina Travis | ... | Judge 1 (uncredited) |
 | Millie Wannamaker | ... | Pagent Guest / TownResident (uncredited) |
| Kenny Waymack Jr. | ... | Party Guest (uncredited) |
 | Memi West | ... | Pageant (uncredited) |
 | Justin Wheelon | ... | Alex Matthews (uncredited) |
 | Lawrence Whitener | ... | Key West Codger (uncredited) |
 | Ebony Wilson | ... | Stark Employee (uncredited) |
 | Lauren York | ... | Miss Johnson City (uncredited) |